I just bought UR22C. It worked fine with Garageband out of the box.
Then I installed the Tools and upgraded the firmware – it stopped to work.Garageband couldn’t recognise the source, and it has not choosable using the installed control panel or the midi-settings
Then I uninstalled the software from Steinberg (USB Driver and tools) – and it worked again.
Conclusion: Steinberg should either fix this problem or inform users to not install the software if the intention is to use UR22C with Garageband.