UR44 Can't acces hardware setup in cubase

If I have already start up my iMac and than power the UR44 the hardware setup in Cubase 10 is not available. Also not available in the mixer (hardware input). I have to restart my iMac with the UR44 powered on than it is available. Is this normal or is there a way to start the UR44 after the iMac is already started and have the hardware setup available?

iMac (late 2012) High Siera, Cubase 10 (10.0.15) UR44 (v.1.10.4)