I am just going through the horrors of new system configuration with a new (refurb) PC running Win 11 and Reason 13 upgrade. I have managed to get the internal instruments and sounds to play within R13, and my Behrnger UMC1820 interface is working for sending and receiving audio in Reason, but this is not the case from the UR44 interface.
In Preferences within Reason I see a red cross when I try to select the installed Yamaha Steinberg USB driver for audio - it only lets me select MME Line UR44, but still no audio is registering to the audio record channel in Reason.