I have a UR44C, and for the last year (at least), I’ve had the weirdest problem:
The audio still works for the most part, but the UI stops showing meter levels, phantom power on/off, etc. Yesterday, I also had problems with Cubase, with track inspector sections that suddenly didn’t open. Then I realized that UR44C registers as a section as well. And low and behold - a reinstall of the UR44C drivers/software solved it.
Long story short - this problem typically occurs after a Windows Update, or after a software installation with a C++ redistributable as part of their installer.
Could it be that the UR44C software installs its dependency in a general location, and that it gets overwritten?