UR824 Audio

Hi guys and gals,
My UR824 has been working as my audio interface on my W10 PC for several years. Recently, something seems to have changed and now Cubase needs to be open to hear audio from other players and apps eg iTunes YouTube…
If Cubase is shut whilst something else is playing, the sound disappears again.
Any ideas would be appreciated.
Many thanks.
Drivers updated. Cubase 9.5

I would check two things: First that windows audio is set to UR824 outputs 1&2, and then open Dspmixfx just to make sure nothing has somehow got messed up there.