Will all my LE, PLE and macros created under Cubase 11 still work?

I use a lot the logic editor the project logic editor and macros through a touch screen and the sherlock plugin
Will all my parameter shortcuts with my keys continue to work with the Cubase 12 update?
Or do we have to reconfigure everything since the editor has changed

Yes
.

yes to the first question or the second?

both.