Win10 Build 1607 Compatibility - Cubase 10.5

Cubase Wizards,

I understand that Steinberg’s official documentation states that Cubase 10.5 is compatible on builds 1903 and 1809,

but realistically speaking is there incompatibility between newer Cubase versions and older Win10 builds?

In a nutshell if I were to use 10.5 on 1607 should I be expecting any particular issue, or is it simply because Steinberg’s QA team only tests on the latest builds?

Thanks, cheers.