Hi there. Same thing here with Windows 10. Are you using AMD cpu and chipset?. The mixer was working OK until I decided yesterday to install the new update of the AMD X570 chipset drivers (Ver 4.06.10.651) and the new Radeon video software. The audio started to work intermittently in all the software that uses sound. After some test I realize that the USB port was stopping recognizing the MG10XU mixer and jumping to the Realtek sound chip embedded in the motherboard (that I don’t use but it is there). I reported the problem to AMD since it started with the update of the chipset drivers. My son tested the mixer in his iMac without any problem. I uploaded a video in YT to show what is happening, but the forum engine didn’t allow me to post the link here. Search for “Intermittent audio dropouts issue with YAMAHA MG10XU USB mixer” in YT.