GNP - just posted this in another thread, which covers some of my experiences I already mentioned in this thread:
There are some plugins - quite a few - that cause a total Cubase 10 meltdown that weren’t a problem in earlier versions. There are a variety of methods to track it down - I imported blocks of tracks from a problem 9.0 project into a blank 10.0 one, found they all loaded ok so deduced it had to be in the FX or groups channels, which was about a dozen plugins. I loaded those into a blank project one by one til Cubase crashed. In my case it was the 1.0.0 version of Kush’s Clariphonic. I updated to 1.1.1 and now all is well.