I used a Nektar Panorama CS12 with Nuendo 14 and eventually had to return it. The concept is awesome. It was so nice having so much integration and control in a single controller. However, in practice it was very sluggish. The response time from clicking on a track to the CS12 updating the screen was 1-2 seconds which might not seem like but for a professional workflow, it was just too much. I know part of it has to do with the MIDI Remote because that’s what it uses. But I’m sure they could develop a “lite” version where you don’t have all the super deep functionality (much of which I would have never used) and it probably would be considerably faster. It was just too much to handle via MIDI Remote.
I had to just accept it and continue with my current setup SSL UF1 + Metagrid Pro on iPad + Stream Deck. I just ordered a CC1 and looking forward to trying it to see if it’s able to replace the UF1 + Stream Deck combo. Combining both into a single controller would be really nice.