Cubase leaves my UR22 silent after i close it

As far as I know there is a bug with the latest driver version which causes the issue you describe.
The only way to fix it is to install the previous 2.0.4 version.
It’s explained here :
https://helpcenter.steinberg.de/hc/en-us/articles/6092392859026-Windows-Issues-with-Yamaha-Steinberg-USB-Driver-V2-1-0-or-later

Also, you shouldn’t be using Release Driver since it can cause more issues.
Please read the Audio Setup Guide.

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