I currently have 5.5.3 successfully running under Lion on a late 2006 MacBook with a Line 6 Toneport UX1.
A word of caution - unless you’re having problems, do NOT follow Steinberg’s instructions to delete the VSTPluginManager.bundle. This will cause you to lose access to all your non VST3 plugins.
agreed, as I outlined in the thread below it ended up causing me to lose a few hours in troubleshooting and reinstalling… a better solution is to just remove PPC pugins (there really aren’t so many left)
i’m also running fine under Lion on an early 2008 MBP (Cubase Studio 5.5.3), NI Audio Kontrol 1 (my M-Audio Firewire 410 just cause a kernel panic if its inserted into the Firewire port, and M-Audio will not update the drives for it).
back to full production… and happy 