@Inplanto: Don’t check whether the software is 64 bit. Go into your Windows Device Manager and get the driver information there. If the Yamaha 1.9.9 driver is 64bit, you’re good. 
Hello everybody,
it seems I should have looked more in depth for problems of this audio device, since I, too, suffer from seemingly random audio drop-outs. It seems to me that the UR22 has problems with an AMD chipset, mostly a Phenom II X4. I’m having an older system and plan to upgrade in the foreseeable future, but for the moment it’s what I mostly use.
My windows system I am using has
Windows 10 Pro 64bit
AMD Phenom II X4 940 3000MHz
Gigabyte GA-MA770-UD3
8GB DDR2 RAM
Radeon R9 270X
I haven’t tried out all of the possible solutions, but what I did so far was:
Tried to plug the UR22 into different USB back ports from the PC - Some were AWFUL and I couldn’t even play a wave file properly, others work with the occasional drop outs
Tried to plug the card into a USB port of a PCI USB card - Same effect as in the “good” port on the back
Used an external power adapter to power up the card - no difference whatsoever
Removed everything else from the USB ports except for keyboard, mouse and the card - no difference
Firmware and drivers are up to date.
I realized that the dropouts seem to happen randomly but they happen more often under certain circumstances. I don’t use my system solely for audio production, but also for gaming and streaming. A reason why I bought this card was to use my XLR microphone as a stream microphone. I noticed that when I ran OBS Studio(a popular streaming and screen recording software) on the side, the dropouts happened to be more frequently up to making playing games unbearable. Especially when the game is a tad more demanding for the processor and GPU.
For example, I started Playdead’s INSIDE and opened Open Broadcaster Software to capture the game. Even without recording a video or streaming, just with the preview open, the audio started to drop out extremely frequently, with all other USB devices removed.
I really like this card and its build quality; I didn’t have any trouble while using it on my Mac, which instantly made me believe this was some sort of bad chipset combination.
I know that AMD is not at the front of the market with its processors and many professionals don’t use their hardware. I plan on getting an Intel for my next machine as well. However, the lack of support for AMD chipsets makes me really angry and sad. Reading through this thread, interfaces from other manufacturers, heck, even my horrible TASCAM one that I used for way too long, have less trouble. You shouldn’t have to reconfigure your whole system via BIOS when other manufacturers just seem to get it right.