Did you get this sorted, I have the old UR22 and never had
any issues with this, and I have ran it with usb suspend enabled
and disabled on computers that were not mine to play with.
I am thinking about this UR22ii for my ipad, but would like it to
work on windows too, even linux, my old UR22 wont work on ipad,
but was perfect on windows linux and my sons mac book pro.
I would suggest turning off everything that could interfere with recording audio
on your computer, everything that can interrupt the processor is a possible problem
on any audio setup, windows home edition will be a nightmare because it will keep
trying to update, this will cause you trouble in many ways, first resources, then interupts
and then break something that previously worked.
As mentioned, try and prevent your usb devices including hub controller from changing state
and going to sleep or on to lower power setting, same for hard drive, same for monitor state.
Turn off your computers internal mic too, its unlikely you will be recording with it,
disable or turn off bluetooth or networks that you are not using, they too interrupt and cause
issues, have a look at this pdf, it goes into detail regarding such issues, well worth a read,
https://download.cantabilesoftware.com/GlitchFree.pdf
EDIT, one annoying point on windows, it is better to use the same port you
initially used to install the likes of a usb interface on for that interface,
mac or linux do not care if you use a different port, but windows can
have issues, and use usb2 ports if you can, some problems have been resolved
by avoiding usb3 ports.
Hope you get sorted