I have Cubase 10.5.10, and Steinberg UR44 interface. I have the interface buffer at the max of 2048 (It needs larger obviously).
I have a project loaded which is apparently taxing my system. After the system overloads and playback doesn’t work, the Cubase cpu meter is pumping from about 4/5 load to full load every second or so as long Cubase is attempting to play audio (including reverb tails, etc.), and playback will not happen.